1,2,3-Trifluorobenzene

Product Name: 1,2,3-Trifluorobenzene
Chemical Formula: C₆H₃F₃
CAS: 1489-53-8
HS Code: 2903999090
Molecular Weight: 132.08
Structural Formula: 1,2,3-Trifluorobenzene-1.jpg

product details

BRIEF DESCRIPTION

1,2,3-Trifluorobenzene is a colorless, transparent, flammable liquid. As a fluorinecontaining aromatic intermediate, it is widely used in the synthesis of fluorinated pharmaceuticals and fine chemicals.

TECHNICAL INDICATORS

Items	Result
Appearance	Colorless transparent liquid
Density	1.28 g/mL (25℃)
Vapor pressure	56.1 mmHg (25℃)
Purity (%)	≥99.8%

APPLICATIONS

1. Pharmaceutical intermediate: Used to produce 2,3,4‑trifluoronitrobenzene, a key building block for quinolone antibacterial drugs such as ofloxacin and levofloxacin. Also used in the preparation of antiviral agents (e.g., the fluorinated benzene fragment of laninamivir).

2. Pesticide intermediate: Employed in the synthesis of fluorine‑containing diphenyl ether herbicides and insecticides, for example, the preparation of benzoxazole insecticides via nitration‑reduction‑cyclization.

3. Liquid crystal materials: Introduced as a polar side chain into liquid crystal molecules to enhance dielectric anisotropy, used in fast‑response TFT‑LCD formulations.

4. Organic electronic materials: Used in the synthesis of electron transport materials or hole‑blocking layer substrates for organic light‑emitting diodes.

STORAGE CONDITIONS

1. Store in a cool, dry, well‑ventilated area, in a flammable materials storage zone.

2. For long‑term storage, refrigerate at 2–8°C; ensure good ventilation or exhaust during handling.

3. Keep container tightly sealed, separate from strong oxidizing agents – do not mix storage.

4. Keep away from ignition sources and heat; do not use spark‑producing tools or equipment.

5. The storage area should be equipped with spill containment and appropriate collection materials.

PACKAGE

1. Sealed glass bottles, plastic bottles or steel drums, with outer wooden packaging.

2. Other packaging forms available upon request.

CHEMICAL PROPERTIES

Boiling point: 94–95°C, flash point: –3°C (extremely flammable), refractive index: 1.4230. The strong electron-withdrawing effect of the three fluorine atoms makes the benzene ring highly electron-deficient, favoring nucleophilic substitution (especially at positions 2 and 4). Unstable in the presence of base; at high temperature and strong base conditions, fluorine atoms may undergo hydrolysis. It is highly flammable when exposed to open flame or high heat; store in a cool, well-ventilated area.