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- 2. 4. 6-Trifluorobenzonitrile
1‑Bromo‑2,4‑dichlorobenzene
Product Name: 1‑Bromo‑2,4‑dichlorobenzene
Chemical Formula: C₆H₃BrCl₂
Synonym: 2,4-Dichlorobromobenzene
CAS: 1193-72-2
HS Code: 29039990
Molecular Weight: 225.90
Structural Formula: 214-778-6
BRIEF DESCRIPTION
1-Bromo-2,4-dichlorobenzene is a white to pale yellow crystalline powder. The unsymmetrical substitution pattern provides regioselectivity in coupling reactions, making it an important chemical intermediate.
TECHNICAL INDICATORS
| Items | Result |
| Appearance | White to pale yellow crystalline powder |
| Density | 1.89 g/cm³ |
| Vapor pressure | 0.0714 mmHg (25°C) |
| Purity (%) | ≥99% |
APPLICATIONS
1. Pharmaceutical intermediate: Used in the synthesis of antimalarial drugs (e.g., chloroquine halogenated derivatives) and anti‑inflammatory agents (e.g., bromine‑containing precursors of diclofenac). Example: conversion of bromine to cyano, followed by hydrolysis to 2,4‑dichlorobenzoic acid, then preparation of amide‑type analgesics.
2. Pesticide intermediate: Used for triazole alcohol fungicides (e.g., halogenated benzene ring of tebuconazole) and acaricides (e.g., analogues of pyridaben).
3. Dyes and pigments: Used as a halogenated aromatic component in phthalocyanine blue and green pigments to adjust shade and fastness.
4. Polymer additives: As an intermediate for brominated flame retardants, used in the preparation of low‑oligomeric brominated diphenyl ethers.
STORAGE CONDITIONS
1. Store in a cool, dry, well‑ventilated area.
2. Keep container tightly sealed; store under inert gas, avoid moisture.
3. Separate from oxidizing agents – do not mix storage.
4. Ventilation systems should be equipped with static electricity grounding.
5. The storage area should be equipped with spill containment and appropriate collection materials.
PACKAGE
1.Tightly sealed container.
2.Other packaging forms available upon request.
CHEMICAL PROPERTIES
Melting point: 26–30°C (may partially liquefy at room temperature), boiling point: 235°C, flash point: >110°C. The bromine atom is ortho to one chlorine and para to the other, making it susceptible to metalation. Low vapor pressure (0.07 mmHg) indicates low volatility. Skin irritant; wear protective gloves when handling.
PICTURE
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