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2,3-Difluoroanisole
Product Name: 2,3-Difluoroanisole
Chemical Formula: C₇H₆F₂O
Synonym: 1,2-Difluoro-3-methoxybenzene
CAS: 134364-69-5
HS Code: 29093090
Molecular Weight: 144.12
Structural Formula: 
BRIEF DESCRIPTION
2,3-Difluoroanisole is a colorless liquid. As a fluorinecontaining building block, it is used in pharmaceuticals, liquid crystal materials, and coordination chemistry.
TECHNICAL INDICATORS
| Items | Result |
| Appearance | Colorless liquid |
| Density | 1.24 g/mL |
| Vapor pressure | 6.4 mmHg (25°C) |
| Purity (%) | ≥99.5% |
APPLICATIONS
1. Pharmaceutical intermediate: Used in the synthesis of multi‑target kinase inhibitors, such as fluorinated quinazoline antitumor agents. Example: nitration‑reduction to give 2,3‑difluoro‑4‑methoxyaniline, which is further used to prepare AZD‑9291 (osimertinib) analogues.
2. Pesticide intermediate: Used to prepare benzamide insecticides (e.g., fluorine‑containing derivatives of chlorantraniliprole) and herbicides (e.g., trifluralin analogues).
3. Liquid crystal materials: Acts as a terminal group in negative‑dielectric LC materials; the combination of fluorine atoms and a methoxy group allows tuning of dielectric anisotropy and optical birefringence.
4. Supramolecular chemistry building block: Serves as a ligand for synthesizing metal‑organic frameworks (MOFs); the methoxy group can be further derivatized to a carboxyl group for metal coordination.
STORAGE CONDITIONS
1. Store in a cool, dry, well‑ventilated area.
2. Keep container tightly sealed; store in a cool, dark place away from direct sunlight.
3. Separate from oxidizing agents – do not mix storage.
4. Ventilation systems should be equipped with static electricity grounding.
5. The storage area should be equipped with spill containment and appropriate collection materials.
PACKAGE
1. Sealed glass bottles or plastic drums, with outer wooden packaging.
2. Other packaging forms available upon request.
CHEMICAL PROPERTIES
Boiling point: ca. 144.5°C, flash point: 47.1°C, refractive index: 1.452. The methoxy group is ortho/para‑directing, but the electron‑withdrawing effect of the adjacent fluorine atoms makes the benzene ring overall electron‑deficient; electrophilic substitution occurs at the position meta to the fluorine atoms (the 5‑position). Vapor pressure of 6.4 mmHg (25°C) indicates moderate volatility; use with adequate ventilation.
PICTURE
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