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2-Fluoro-4-bromochlorobenzene
Product Name: 2-Fluoro-4-bromochlorobenzene
Chemical Formula: C₆H₃BrClF
Synonyms: 2-Bromo-4-fluorochlorobenzene, 2-Bromo-1-chloro-4-fluorobenzene
CAS: 60811-18-9
HS Code: 29039990
Molecular Weight: 209.44
Einecs: 612-035-4
Structural Formula: 
BRIEF DESCRIPTION
2-Fluoro-4-bromochlorobenzene is a colorless to pale yellow liquid containing three halogens (chlorine, bromine, and fluorine). Selective coupling reactions allow sequential introduction of various substituents.
TECHNICAL INDICATORS
| Items | Result |
| Appearance | Colorless to pale yellow clear liquid |
| Density | 1.75 g/mL |
| Vapor pressure | 0.102 mmHg (25°C) |
| Purity (%) | ≥99.5% |
APPLICATIONS
1. Pharmaceutical intermediate: Used in the synthesis of JAK inhibitors (e.g., fluorinated aromatic rings of tofacitinib) and antiviral drugs (e.g., benzene ring derivatives of peramivir). Example: Suzuki coupling at the bromine position to introduce a heterocycle, while retaining chlorine and fluorine as pharmacophores.
2. Pesticide intermediate: Used to prepare amide‑type insect growth regulators (e.g., the fluoro‑bromo‑chlorobenzene fragment of lufenuron) and herbicides (e.g., benzene ring analogues of florpyrauxifen).
3. Liquid crystal materials: Multi‑halogen substitution allows tuning of LC polarity for fast‑response LCD development.
4. Organometallic complexes: As a ligand precursor, used in C−H activation to construct cyclometalated iridium and platinum complexes for OLED phosphorescent materials.
STORAGE CONDITIONS
1. Store in a cool, dry, well‑ventilated area; recommended storage temperature below 15°C.
2. Keep container tightly sealed; store in a cool, dark place away from direct sunlight.
3. Separate from oxidizing agents and food containers – do not mix storage.
4. Ventilation systems should be equipped with static electricity grounding.
5. The storage area should be equipped with spill containment and appropriate collection materials.
PACKAGE
1. Tightly sealed container.
2. Other packaging forms available upon request.
CHEMICAL PROPERTIES
Boiling point: ca. 202.1°C (760 mmHg), flash point: ca. 76°C, refractive index: ca. 1.5530. The order of reactivity of the three halogens is Br > Cl > F. Thus, palladiumcatalyzed coupling can be performed first at the bromine site, followed by more forceful coupling at the chlorine site. Low vapor pressure implies slow evaporation, but inhalation is still toxic; ensure good ventilation.
PICTURE
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