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0102030405
4-Benzyl-2-Hydroxy-Morpholin-3-One
Product Name: 4-Benzyl-2-Hydroxy-Morpholin-3-One
Synonyms: Aprepitantimpurity48;Fosaprepitantimpurity23;3-Morpholinone,2-Hydroxy-4-(Phenylmethyl)-;2-Hydroxychemicalbook-4-(Phenylmethyl)-3-Morpholinone;Fosaprepitantimpurityb
CAS: 287930-73-8
Molecular formula: C11H13NO2
Molecular weight: 207.23
Einecs: 811-794-0
Dangerous goods transport number：/
Structural formula：
BRIEF DESCRIPTION
2-Hydroxy-4-(phenylmethyl)-3-morpholinone, is an intermediate used for the synthesis of NK1 Receptor Antagonist Aprepitant, used as as antiemetic drugs.
TECHNICAL INDICATORS
Analysis |
Requirement |
Exterior |
White to Off-White |
purity |
98% |
Boiling point(℃) |
441.7±45.0°C |
Melting point(℃) |
134.0 to 138.0°C |
Density℃(kg/m) |
1.292±0.06g/cm3 |
Purpose (USE)
4-Benzyl-2-hydroxy-morpholin-3-one has certain application value in the medical field, and it mainly has the following uses:
1. Antibacterial agent: It has certain antibacterial activity and can be used to prepare antibacterial drugs or as an intermediate for antibacterial agents.
2. Analgesic: This compound can be used as a raw material for the synthesis of analgesics.
It is used to treat depression and chemotherapy-induced vomiting; it can prevent acute and delayed nausea and vomiting caused by the first and subsequent repeated chemotherapy. API Aprepitant/Aprepitant key intermediate
STORAGE CONDITIONS
When storing and handling this compound, follow proper safety procedures, avoid sources of ignition and avoid contact with oxidizing agents.
PACKAGE
25kg/cardboard drum packaging
CHEMICAL PROPERTIES
Solubility : DMSO(Slightly),Methanol(Slightly,Heated)
Acidity coefficient (pKa) : 11.00±0.20(Predicted)
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