(R)-1-[3,5-Bis(Trifluoromethyl)Phenyl]Ethanol

(R）-1-[3,5-bis(trifluoromethyl)phenyl]ethanol is an important chiral intermediate in the synthesis of the antiemetic drug Aprepitant, which was approved by the U.S. Food and Drug Administration in 2003 It is a drug approved by the Food and Drug Administration (FDA) to reduce vomiting and delayed vomiting. At the same time, this alcohol is also an important chiral intermediate for NK receptor antagonists and synthetic antidepressants. There have been reports about (R)-1-[3 , The synthesis methods of 5-bis(trifluoromethyl)phenyl]ethanol mainly include chemical methods and biological methods. Although the above two methods have achieved relatively good results, these two methods still have many shortcomings.