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Ethyl bromodifluoroacetate (BDFA)

Product Name: Ethyl bromodifluoroacetate

Abbreviation: BDFA

Synonyms: BROMODIFLUOROACETICACIDETHYLESTER;2-Bromo-2,2-difluoroaceticacidethylester;Difluorobromoaceticacidethylester;Ethyl2,2-DifluChemicalbookoro-2-Bromoac;Ethylbromodifluoroa;2-Bromo-2,2-difluoro-1-ethoxyethan-1-one,2-Bromo-2,2-difluoro-1-ethoxy-1-oxoethane;EthylbroModifluoroacetate,98%5GR

CAS: 667-27-6

Molecular formula: C4H5BrF2O2

Molecular weight: 202.98

Einecs: 2211-567-0

Dangerous goods transport number: UN 2924 3/PG 2

Structural formula: BDFA-structural-formula.png


    Ethyl difluorobromoacetate compound is an intermediate in the synthesis of drugs and high-energy materials. For example, ethyl difluorobromoacetate is an intermediate for the anti-tumor drug gemcitabine.



    Analysis Requirement
    Appearance Colorless Transparent Liquid
    Purity (% by weight) 99.29%
    ≤0.50% 0.25%
    ≤0.20% 0.20%
    Boiling Point (℃) 112 °C/700 mmHg (lit.)
    Density (kg/m) 1.583 g/mL at 25 °C (lit.)
    Flash Point (℃) 70 °F


    1. As an important organic synthesis intermediate, ethyl difluorobromoacetate is widely used in pharmaceuticals, pesticides and other fields.
    2. It can be used to synthesize fluorine-containing organic compounds, such as fluoroketones, fluoramides, etc.


    1. During the operation of ethyl difluorobromoacetate, you need to pay attention to protective equipment, including respirators, protective glasses and gloves.
    2. When storing at room temperature, the container needs to be kept sealed to avoid reaction with moisture in the air.
    3. Open flames and high temperatures should be avoided during use and storage to prevent fire and explosion.
    4. Avoid contact with skin and eyes. In case of accidental contact, rinse immediately with plenty of water and seek medical help.




    Ethyl difluorobromoacetate is a colorless and transparent liquid. It is an important organic synthesis intermediate and is often used in the synthesis of drugs and pesticides with biological enzyme functions. In ethyl difluorobromoacetate, CF2 with strong biological activity is introduced into the compound by replacing the bromine atom. The fluorine in the α position of these compounds increases the electrophilicity of the carbonyl group, which increases the active site of biological enzymes.


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